Dimethylglycine (also known as DMG) is a derivative of the amino acid glycine. It is found naturally in plant and animal cells and in certain foods such as beans, cereal grains, and liver.

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Learn more about Dimethylglycine (Dmg) uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Dimethylglycine (Dmg).

N, N-Dimethylglycine (DMG) /Ingredients /N, N-Dimethylglycine (DMG) Ingredients. Dimethylglycine is an amino acid, a building block for protein. It is found in the body in very small amounts and for only seconds at a time. People use dimethylglycine to make medicine.
Early clinical research shows that taking low doses of dimethylglycine daily for 1 month does not improve symptoms of autism.

Dimethylglycine acts as a building block for many important substances in the body including amino acids, hormones and neuro-transmitters. It also appears to play an important role in neurological functions and in the immune system.

Some people think that some individuals on the autism spectrum have a range of nutritional and metabolic problems. These include low levels of nutrients, high levels of oxidative stress (a chemical state within cells that can increase cellular damage) and difficulties with metabolic processes (such as digestion).

Some people think that these nutritional and metabolic differences may be the cause of some of the core features of autism (such as impaired communication and social difficulties) and related issues (such as challenging behaviours).

They also believe that by taking dietary supplements, such as dimethylglycine, they can reduce some of those symptoms. However, the exact mechanism by which dimethylglycine might do this is unclear

Our Opinion

There is currently no agreement amongst scientists as to whether individuals on the autism spectrum have a particular pattern of vitamin, mineral or other nutrient deficiency.

There is a limited amount of research evidence, based on two scientifically valid and reliable trails, to suggest that dimethylglycine is not effective in improving social, language or other functioning in children and adults on the autism spectrum.

However there are many positive anecdotal reports about the benefits of dimethylglycine, which is relatively cheap, easy to use, and appears to have no significant side effects for most people.

For these reasons, we believe that further research into dimethylglycine may be justified.

Disclaimer

Please read our Disclaimer on Autism Interventions

Audience

According to the WebMD website, accessed on 16 January 2017, dimethylglycine is used by people with a range of conditions including:

“.. attention deficit-hyperactivity disorder (ADHD), epilepsy, chronic fatigue syndrome (CFS), allergies, respiratory disorders, pain and swelling (inflammation), cancer, alcoholism, and drug addiction.

The WebMD website goes on to state that DMG

“… is also used to improve speech and behavior in autism, nervous system function, liver function, the body’s use of oxygen, and athletic performance. “

The WebMD website also states, however, that there is insufficient evidence to determine if DMG is effective for most of these conditions and that it is probably ineffective for conditions such as autism and epilepsy.

Key Features

According to the Memorial Sloan Kettering Cancer Center website, accessed on 16 January 2017,

“Dimethylglycine (DMG) is a derivative of the amino acid glycine. It is found naturally in plant and animal cells and in certain foods such as beans, cereal grains, and liver. DMG is produced in cells during the metabolism of choline and is considered an antioxidant and enhancer of oxygenation at the cellular level”

According to the Autism Research Institute (2008),

“Dimethylglycine is technically classified as a food. It is found, in very small amounts, in some foods, such as brown rice and liver. Chemically and physiologically, it resembles the water-soluble vitamins, such as the B vitamins. The main reason it is not classified as a vitamin is that there are no specific symptoms associated with a deficiency of DMG.”

DMG comes in a variety of forms including capsules, tablets and in liquid form.

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Dosage

According to the WebMD website, accessed on 16 January 2017,

“The appropriate dose of dimethylglycine depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for dimethylglycine. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.”

Aims and Claims

Aims

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They also believe that by taking dietary supplements, such as dimethylglycine, they can reduce some of those symptoms. However the exact mechanism by which dimethylglycine might do this is unclear.

For example, Bolman and Richmond (1999) speculated that DMG might act as a neurotransmitter, changing the rate of amino acid activity in the brain, enabling it to work more effectively. Kern et al (2001), speculated that DMG might increase methylation, leading to a reduction in lactic acid build-up and enhanced oxygen use during times of hypoxia, enabling the body to work more effectively.

Claims

There have been numerous claims made for the use of dimethylglycine supplements as an intervention for people on the autism spectrum. For example:

Rimland (1990) reported “In some cases dramatic results have been seen within 24 hours: A Los Angeles mother was driving on the freeway, three-year-old Kathy in the back seat, five-year-old mute autistic son Sammy in the front. DMG had been started the day before. Kathy began to cry. Sammy turned and spoke his first words: ‘Don't cry, Kathy.’ The mother, stunned, almost crashed the car.”

The Autism Research Institute (2008) claims that “Many parents have reported that, within a few days of starting DMG, the child's behavior improved noticeably, better eye contact was seen, frustration tolerance increased, the child's speech improved, or more interest and ability in speaking was observed.”

Rimland also claims (2001) that “Over the past 40 years I have encountered a great many cases of severely SIB/A [self-injurious and assaultive behavior] individuals who have responded wonderfully well to nutritional supplementation, particularly high dose B6 and magnesium, and DMG.”

Cost and Time

Cost

The cost of buying DMG supplements depends on a range of factors including the quantity you buy, the supplier, delivery charges etc.

We found a wide range of suppliers providing DMG supplements for a wide range of prices when we did an online search on 27 January 2017. Prices varied from £6.50 to £28.99 for 1

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